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This family accommodates only one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was discovered to methylate, Law Firm in addition to histone, quite a lot of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and components of the TATA binding protein (TBP) complex, TBP-related factors TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Okay/R-S/T-Okay (goal lysine is bold), is also recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of removing the methyl mark on most of these substrates 17 , 94 Subsequently KMT7/KDM1A has emerged as a traditional mannequin for dynamic lysine methylation of each histone and non-histone proteins.
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